Day 10 was probably the most fun so far for me! I had this idea in mind from the beginning and really wanted to do this and it turned out awesome! The material is split in 4 graphs, each containing one element.

The color spots are done by a custom generator and can be tweaked in various ways to create fast variation.
The color tube and mixing palette can be tweaked as well.
The canvas is completely procedurally generated, besides the actual painting that is taken from a texture map of a painting of Bob Ross (Yeah I know, no image textures, but I really did not care here, as the focus is on all the smaller part nonetheless).

100% Substance Designer (Except Bob Ross)
Rendered in Marmoset Toolbag
Texture Breakdown with Markus Pohl's "Texture Breakdown Tool"